Saltidin (Picaridin): Scientific information2018-07-31T01:30:04+00:00

Saltidin (Picaridin): Scientific information

What is Saltidin (also known as Picaridin and Icaridin)?

Saltidin is an active ingredient with a broad-spectrum of effectiveness. It prevents bites from numerous species of arthropods. Saltidin repellents are intended to be used by the general public, including adults and children.123

Saltidin
Chemical Overview

Chemical type Pesticide – insect and acarid repellent
Chemical family Piperidines
Common names Picaridin, icaridin, KBR 3023, propidine
Trade names Bayrepel®, Saltidin®
INCI name Hydroxyethyl isobutyl piperidine carboxylate
IUPAC name 1-piperidinecarboxylic acid 2-(2-hydroxyethyl)-1-­methylpropylester
CA name sec-Butyl 2-(2-hydroxyethyl) piperidine-1-carboxylate
CAS No. 119515-38-7
Molecular formula C12H23NO3
Molecular mass 229.3 g/mol
Physical state Liquid
Odor Nearly odorless
Color Colorless
Molecular Structure Saltidin (Picaridin) molecular structure_Proven_Insect_Repellent

Picaridin_Proven_Insect-Repellent_Lotion_Spray

History

A Need for New Repellents

DEET has been the standard insect repellent since becoming commercially available in 1957.4 However, there are increasing concerns related to health. DEET also has an unpleasant smell, a sticky feeling on skin, and it dissolves plastics. These traits have led to a demand for identifying new repellent molecules.5678

The Development of Saltidin

Picaridin was developed by Bayer AG in the 1980s.3 The repellent was first released under the trade name Bayrepel and sold under the brand Autan.91 In 2008, LANXESS and Saltigo split off from Bayer, and the trade name was changed Saltidin.10

Saltidin is part of a new generation of customized repellents. Molecular modeling techniques were used to map and construct three-dimensional molecules. Saltidin was designed under the hypothesis that the repellent effect was caused by interaction with an insect’s olfactory (smell) receptors.1 Known repellent compounds were altered at sites where interaction with receptors was anticipated. Through this process, more than 800 substances were synthesized and screened for efficacy, safety and compatibility with skin. Of these compounds, Saltidin (KBR 3023) was the best candidate.111 It became the first synthetic repellent to go through modern efficacy and safety tests as part of the creation process.212

Saltidin’s molecular structure is based on piperidine, a colorless organic compound with a peppery odor.131415 It’s similar to the alkaloid in peppers (piperine) that creates the hot flavor.1615 Saltidin is colorless, odorless, non-greasy, and compatible with skin, gear and plastic.3171

Consumer Availability

Picaridin has been in public use since 1998 in Australia and since 2001 in Europe.18195132021 It was registered with the Environmental Protection Agency (EPA) in 2001.17  Picaridin has enjoyed significant market penetration since its inception. It’s now registered as an insect repelling active ingredient in over 50 countries.3222

Registration & Recommendations

In 2000, the World Health Organization (WHO) recommended picaridin as the repellent of choice for malaria prevention.1 In 2001, the EPA registered picaridin for commercial use, stating that it wasn’t significantly toxic.23 Insect repellents don’t require FDA approval.20 In 2005, the Centers for Disease Control (CDC) added picaridin to their list of recommended repellents for prevention of arthropod-borne illness.32018

Saltidin vs DEET

DEET has been the most widely used repellent for six decades.19 DEET is patent-free and cost-efficient. Though DEET is popularly used, there are drawbacks related to its cosmetic properties. It also isn’t the best repellent against certain biting arthropods like ticks.25 These downsides allow for market penetration of alternative repellents. Saltidin, for example, is better tolerated on skin, has a lower toxicity and is better in efficacy compared to similar percentages of DEET.1971324

Cosmetic Properties

Saltidin has near-ideal cosmetic properties. It’s compatible with skin, mucous membranes and plastic materials. The compound is stable toward light, water, sweat and oxidation.1 It’s also biodegradable.26 Saltidin is odorless, doesn’t feel sticky or greasy, and skin irritation is uncommon.192126 Those surveyed repeatedly report they prefer Saltidin to DEET because of these properties.2721

User Acceptability

A questionnaire regarding insect repellent use was given to the Australian Defence Force. Of the soldiers surveyed, 80% won’t use the issued repellent (35% DEET gel) during their deployment because it feels unpleasant and dissolves plastics. In 2001, 150 soldiers were asked to compare the 35% DEET gel with a 19.2% Saltidin pump spray. The soldiers used each repellent for a week, applying it twice a day. Saltidin was preferred by 94% of the soldiers. DEET caused significantly more reports of skin irritation (see Fig 1).21

Picaridin_vs_Deet_User_Acceptability_Proven_Insect_Repellent

Other user acceptability questionnaires provide similar results. DEET is disliked due to its odor, skin reactions and uncomfortable oily, sticky feeling. Users also don’t like how DEET can damage synthetic clothes, leather, and plastics on eyeglass frames and watches.202721

Efficacy

Targeted Arthropods

Saltidin is a broad-spectrum repellent. It’s effective at repelling a variety of biting arthropods, including mosquitoes, ticks, flies, gnats, chiggers, midges, fleas and sand flies.11928 Saltidin has also been demonstrated to repel ants and cockroaches.29

Effective Duration

Saltidin starts repelling insects immediately after being applied to skin. It develops full performance within a few minutes.1 How long it lasts depends upon the targeted pest. Proven® Insect Repellent Spray has a 20% formulation of Saltidin and protects users from bites for 12 hours. Proven® Lotion also has a 20% formulation of Saltidin and protects for 14 hours.

Saltidin lasts longer on skin than DEET or IR3535. It persists on skin even in high temperatures and moist air.24 This is an important factor considering that moderate levels of physical activity (jogging, cycling) can reduce the protection time of DEET by 40%.33

Against Mosquitoes

Numerous studies have compared the effectiveness of Saltidin and DEET against mosquitoes. Results vary by species, but generally the efficacy of Saltidin is superior to DEET in equal concentrations.7830222427323435 Saltidin has also been demonstrated to be superior to DEET and IR3535 at repelling mosquitoes.2453435

Picaridin_Graph-Mosquitoes-efficacy_Proven_Insect_Repellent

Against Ticks

Saltidin is effective at deterring ticks, demonstrated in studies on lone star ticks (Amblyomma americanum).3613738 Sunscreen repellents slightly decrease efficacy.1

Picaridin_Graph-Ticks-Proven_Insect_Repellent

The protection of DEET against ticks is very low compared with the same percentages of Saltidin.

Against Biting Flies

Saltidin is effective at repelling biting flies, as demonstrated in studies against sand flies (P. duboscqi and P. papatasi) and black flies (Simulium venustum).404142 Against the black fly, Saltidin provided over 95% protection from bites for 8 hours, while DEET only offered 90% protection.42 Against sand flies, 20% formulations of Saltidin performed better to a 50% DEET.41

Against Fleas

Saltidin is an effective repellent of cat fleas (Ctenocephalides felis). 20% Saltidin offers complete protection from flea bites for 9 hours.29

Against No-see-ums

20% Saltidin protects effectively protects against No-see-ums for up to 8 hours after being applied to skin.43

Mode of Action

Insect repellents work through interactions with olfactory receptors (smell) and gustatory receptors (taste).45 Saltidin appears to work by preventing mosquitoes, ticks and other insects from sensing their prey.

Olfactory Receptors

Different repellent compounds have different chemical structures and affect different olfactory receptors (OR). They don’t have a common mode of action.4849 Insect repellents are agonists, activating ORs even in the absence of a host. They’re also antagonists which inhibit the ability of insects to detect nearby hosts. Lastly, repellents are synergistic, hyper-activating the receptors and causing confusion in host detection.5047

Saltidin doesn’t act upon the same receptors that are involved in host attraction. The repellent triggers its own chemosensory response in the antennae. The mode of action isn’t a masking or suppressing effect. Antagonistic effects are caused by receptor cells unrelated to host odors or pheromones that are counteracting the attraction response.11  When Saltidin is presented with an attractant, a new, unique input is activated in the insect’s brain. This scrambled pattern differs greatly from the attractant. The insect can’t understand it. As a result, they can no longer detect the host.11148

Insecticidal Effect

Saltidin doesn’t have any insecticidal effect. However, DEET does. Saltidin also doesn’t affect flight take-off like some other repellent compounds. This provides further evidence that repellents do not behave as a single class of compounds with a common mode of action.52

Oviposition Deterrent

In relatively low doses Saltidin repellents can deter insects from laying eggs. Mosquitoes won’t deposit eggs in areas where the compounds are present. Saltidin repellents are more effective and last longer in water than DEET.53

Antimicrobial Properties

Multiple insect repellents, including Saltidin, have antifungal and antibacterial properties. Saltidin has a stronger antibacterial effect than DEET.6

Toxicity

Picaridin has a good toxicology profile. The WHO has stated it’s a safe and effective insect repellent for human use.27 The EPA concluded that Picaridin is not significantly toxic and can be safely used by adults and children.1 In 2000, Picaridin was recommended as the insect repellent of choice by the World Health Organization due to its safety and cosmetic features.1

Saltidin
Toxicity Data

 

I = Highly Toxic        II = Moderately Toxic              III = Slightly Toxic               IV = Practically Non-Toxic

Acute Dermal Exposure III
Acute Oral Exposure III
Acute Inhalation Exposure IV
Primary Skin Irritation IV
Primary Eye Irritation III
Dermal Sensitizer no
Carcinogen no
Fish II
Aquatic Invertebrates IV
Birds IV

Reports of Adverse Reactions

Skin reactions to Saltidin are rare.2013 There’s only been one report of an adverse effect. In 2005, a man had an allergic reaction to the repellent. However, he was also sensitive to the emulsifier used in the aerosol spray.13

Acute Toxicity

Saltidin has a low acute toxicity to mammals through all routes of exposure. It’s not irritating to skin and only slightly irritating to eyes. It’s practically non-toxic when inhaled and only slightly toxic when swallowed. Saltidin is not a skin sensitizer. No phototoxicity has been observed.27117

Use on Children

Saltidin can be used on babies of 2 months and older. Insect repellents must never be applied to the hands of babies. 20% Saltidin Lotion is the preferred insect repellent for (small) children and face application as there is no chance of inhalation and lotion has the longest duration of protection at 14 hours.

Pregnancy and breastfeeding

Saltidin insect repellents are safe for women who are pregnant or breastfeeding.   Zika is spread mostly by the bite of an infected Aedes species mosquito (Ae. aegypti and Ae. albopictus). These mosquitoes bite during the day and night. Zika can be passed from a pregnant woman to her fetus. Infection during pregnancy can cause certain birth defects.  No vaccine exists to prevent Zika. The mosquitoes that can spread Zika are found throughout the United States. Saltidin repellents like Proven Insect repellent offer the most effective and safe protection against Zika.

Elderly and vulnerable people

Saltidin insect repellents are safe for populations that tend to be most vulnerable to diseases transferred by mosquito and tick bites: like elderly, sick or recovering patients. Only about 1% of people develop severe West Nile virus infection — primarily elderly people and others with weakened immune systems. For (ex) cancer patients it is recommended to use a non-toxic insect repellent like Saltidin base repellents. Saltidin is not likely to contribute to the development of cancer. Researchers did not see increases in cancer among laboratory animals after putting Picaridin on the animals’ skin for two years. The U.S. EPA decided that Picaridin is not likely to cause cancer based on long-term skin exposure studies in rats and mice.

Mucous Membranes

Saltidin has good compatibility with mucous membranes (e.g. nostrils, lips, eyelids and ears).1 DEET, on the other hand, irritates mucous membranes, making facial application inadvisable.13

Skin Absorption & Excretion

Saltidin is poorly absorbed through human skin, and that which gets absorbed is rapidly excreted. About 10% of the applied dose is absorbed through human skin over a 24 hour period.127 In an 8 hour period, less than 4% is absorbed. Over 94% of the absorbed dose gets excreted as metabolites through urine within the first 24 hours. The excretion half-life in humans is 8.2 hours at a low dose. Saltidin doesn’t accumulate in skin.127

Carcinogenicity

Studies haven’t found any carcinogenic or genotoxic effects of Saltidin when applied to skin..14 In 1999, the EPA Health Effects Division’s Hazard Identification Assessment Review Committee (HIARC) determined that Saltidin wasn’t likely to be a carcinogen by the dermal route, and found no evidence of endocrine disruption.117

Reproductive Toxicity

Studies on reproductive toxicity were done with rats and rabbits. There weren’t any statistically significant effects for any reproductive parameters when Saltidin was applied to skin. No developmental toxicity was observed at any dose level.5455

Neurotoxicity

There wasn’t any evidence of acute or chronic neurotoxicity when Saltidin was administered to the skin of rats. It also doesn’t bioaccumlate.2818

Pets & Other animals

Limited information exists on Picaridin’s adverse effects to domestic pets. There was one laboratory study with beagle dogs, and no adverse side effects were seen.46

Dogs aren’t known to get Zika, but they can get West Nile and they often get Heartworms from mosquitoes. People are using Saltidin based products on their pets and it seems to work, but there is no scientific proof. The EPA has recently approved 20% Picardin insect repellent as safe for horses.

Environmental Toxicity

The EPA has stated that Saltidin shouldn’t pose a risk to the environment through the proposed use.17 The WHO found Saltidin’s acute toxicity is low for water fleas (aquatic invertebrate) and rainbow trout.27 The EPA determined it’s moderately toxic to rainbow trout, practically non-toxic to water fleas, and somewhat hinders the growth of green algae. It’s non-toxic to birds.17

Picaridin_mosquito-arm-test-proven_Insect_repellent

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